Genetics of the patent ductus arteriosus (PDA) and pharmacogenetics of PDA treatment

Diameter of the ductus arteriosus as a predictor of patent ductus arteriosus (PDA)

Patent ductus arteriosus (PDA) is the most prevalent cardiovascular defect and is more often seen in females; premature babies are at increased risk. For both sexes, a relationship exists between the risk of this defect occurring and the higher dimensions of the ductus arteriosus. In this study, we examined the relationship between the dimensions of the ductus arteriosus (diameter, length, capa...

Epidemiology, presentation and population genetics of patent ductus arteriosus (PDA) in the Dutch Stabyhoun dog

BACKGROUND Patent ductus arteriosus (PDA) is one of the most common congenital heart defects in dogs and is considered to be a complex, polygenic threshold trait for which a female sex predisposition has been described. Histological studies in dogs suggest that smooth muscle hypoplasia and asymmetry of the ductus tissue is the major cause of PDA. The Stabyhoun population is small and a predispo...

Ibuprofen vs. Indomethacin in the Closure of the Patent Ductus Arteriosus (PDA)

Endocarditis risk of the USCI PDA umbrella for transcatheter closure of patent ductus arteriosus.

BACKGROUND The USCI PDA Umbrella is a device to close patent ductus arteriosus (PDA) by a transcatheter technique. Human clinical trials have shown excellent efficacy in reducing or eliminating the PDA shunt, but concerns remain about the risk of infection with this device. The purpose of this study was to evaluate the risk of infection using an animal model. METHODS AND RESULTS Susceptibilit...

Nonsurgical closure of patent ductus arteriosus: clinical application of the Rashkind PDA Occluder System.

The first successful application of a transcatheter closure technique for patent ductus arteriosus (PDA) suitable for use in infants and children was performed by us in 1977. Since that time, there has been continued improvement and simplification of the equipment as well as in the implantation technique. Following a Food and Drug Administration protocol, a multicenter study was conducted to te...